Energy drinks may stunt muscle repair, new study suggests EnergyDrinks MuscleRegeneration FitnessPerformance MyogenicDifferentiation AthleteHealth Exercise Science Sports Nutrition Physical Performance SciReports
By Dr. Liji Thomas, MDMay 29 2023 Energy drinks have become extremely popular among young people and athletes because of their purported performance-enhancing capabilities. However, despite marketing a wide range of such drinks, often as diet supplements, there is little data on how these affect the differentiation of muscle fibers.
These beverages are unregulated by the US Food and Drug Administration . However, the ingredients in these drinks, including caffeine, sugar, multiple stimulants like taurine, L-carnitine, yerba mate, and ginseng, as well as some vitamins, could increase the risk of multiple diseases affecting the cardiovascular, renal, digestive, and nervous systems, in addition to dental damage.
“This is a growing public health concern because energy drink consumption has been associated with fatal outcomes related to the cardiovascular system such as myocardial infarctions, cardiomyopathies, and sudden cardiac death.” Myogenesis involves an intricate network of regulatory factors, leading to the activation, migration, division, and differentiation of satellite cells into new myotubes, thus restoring the damaged muscle fibers to a healthy state.
With dilutions in differentiation medium, the story took a different turn. Most of the drinks did not produce cell death at 1:50 dilutions, but at 1:5, there was a profound effect, with 20-30% of the cells displaying cytotoxicity. Only RedBull Zero did not show this dramatic shift with dilution. In fact, caffeine has earlier been shown to inhibit myogenesis and to disrupt differentiated myotube function.
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