Enterosignatures provide an interpretable and generic model that enables an intuitive characterization of gut microbiome composition CellCellPress enterosignature gutmicrobiome microbiome microbiota guthealth health gut composition
By Neha MathurJun 21 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Cell Host & Microbe Journal, researchers used a diverse set of 5,230 gut metagenomes [gut microbiome reference dataset] representing human populations from 13 countries, three continents, and different age groups to train a study model.
It confirmed well-recognized ecological characteristics while enabling the detection of any shifts in ESSs community structures. ESS changes with the host’s age; thus, deviations in gut microbiomes assessed by NMF indicated dysbiotic states detrimental to host health. The researchers applied the NMF algorithm to identify ESs signatures, a weighted combination of several genera. They noted that one or two genera strongly dominated some ESs, whereas others were combinations of multiple genera with weaker associations.
The NW samples were distinct in their genus-level composition from the GMR cohort. It helped them test the generalizability of our 5-ES model to samples diverse in age and geography. Three ESs constituted 39% of adult samples termed adult ES, which ES-Firm, ES-Prev, ES-Bact in 44% of cases in combination with the remaining two ESs.
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