Experts urge FDA to include T cell responses when evaluating COVID vaccines TCell Coronavirus Disease COVID US_FDA
By Suchandrima BhowmikAug 11 2022Reviewed by Emily Henderson, B.Sc. Although some remarkable advances have been made in the detection, prevention of severe acute respiratory syndrome coronavirus 2 and treatment of coronavirus disease , the emergence of the recent Omicron variant has highlighted how much there is yet to learn regarding the immune responses of the virus.
Inclusion of both Abs and T cells in the assessment of adaptive immune responses during the beginning of the pandemic could also help to counter misinformation that leads to vaccine hesitancy as well as provide swift messaging. This gap was quite prominent in the initial results of the BNT162b2 vaccine trial in a population whose age ranges from 2 to 5 years which made it insufficient for it to receive emergency use authorization for this population.
They write that it is critical to measure T-cell responses in addition to antibodies to evaluate vaccine efficacy better and make informed decisions regarding ongoing protection against current and future variants. Strengthening of public health response and confidence Protection can have two dimensions, protecting people from getting infected and preventing severe illness from infection. Both the Omicron and Delta variants have sown evasion of antibody responses. However, the emergence of the Omicron variant led to the analysis of T cell importance to balance the loss of Ab-mediated protection.
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