Exploring long- and short-term mortalities among COVID-19 patients medrxivpreprint Cornell WCMQatar SARSCoV2 COVID19 Mortality
By Bhavana KunkalikarFeb 2 2023Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers assessed the longer- and short-term all-cause mortalities among severe acute respiratory syndrome coronavirus 2 -infected patients.
The team assessed the national mortality database along with the national datasets for COVID-19 laboratory testing, immunization, and mortality, which were retrieved via the national platform for digital-health information. A retrospective matched cohort research was performed to explore the incidence of all-cause death noted between a nationwide cohort of individuals with verified primary SARS-CoV-2 infection and a national reference control group including SARS-CoV-2-naive individuals.
Results Each matched cohort comprised 6,85,871 individuals. In the analysis of acute COVID-19 mortality, the median follow-up duration was 91 days. In the primary-infection group, 342 deaths were observed during follow-up, while 288 deaths were noted in the infection-naive group. Among the 342 mortalities, 223 deaths were caused by COVID-19.
During the post-acute period, the aHR comparing mortality incidence in the unvaccinated primary-infection group to the unvaccinated infection-naive group was 0.50. Between the third and seventh month following the main infection, the aHR was 0.41, which rose to 0.76 in the following months. Those who were more clinically susceptible to severe COVID-19 had an aHR of 0.37 during the post-acute phase, while those who were less clinically susceptible to severe COVID-19 had an aHR of 0.77.
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