A study in BMCMedicine finds that individuals with increased faecal haemoglobin concentration are more prone to die from non-communicable diseases seemingly unrelated to colorectal cancer including cancers, respiratory and cardiovascular diseases.
]. To mitigate this uncertainty, we accounted for the potential effect of both types of bleeding in our multivariate analyses.
The strengths of our study include a very large population of screening participants, extensive and individual-level adjustment for confounding effects and our ability to adjust for a numerical f-Hb. Limitations include the risk of misclassification in the registrations from the DRCD, which is affected by the input quality.
Assuming f-Hb is an effective and practical biomarker for non-communicable diseases, several new pathways focusing on maximizing the diagnostic gain from CRC screening and diagnostic initiatives in other clinical areas could be established.
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