The FDA approved a new nasal spray to reverse opioid overdoses
that has been used for decades to quickly counter overdoses of heroin, fentanyl and prescription painkillers. Both work by blocking the effects of opioids in the brain, which can restore normal breathing and blood pressure in people who have recently overdosed.
In studies funded by the federal government, Opvee achieved similar recovery results to Narcan, the leading brand of naloxone nasal spray. Because fentanyl stays in the body longer than heroin and other opioids, some people may require multiple doses of naloxone over several hours to fully reverse an overdose.Scientists at the National Institutes of Health worked with pharmaceutical researchers on a nasal spray version of nalmefene that would quickly resuscitate users, while also protecting them from relapse. Testing and development was funded by more than $18 million in grants from the U.S.
“The risk of long-lasting withdrawal is very real and we try to avoid it,” said Nelson, an emergency medicine physician and former adviser to the FDA on opioids.“We’re not suffering from a naloxone shortage where we need to use an alternative,” he said. “We have plenty of it and it works perfectly well.”
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