FDA mandate to limit acetaminophen in acetaminophen-opioid medications associated with reduced serious liver injury

FDA mandate to limit acetaminophen in acetaminophen-opioidmedications associated with reduced serious liver injury JAMA_current

. Together, the multiple drugs should provide additive synergistic analgesia while minimizing toxicity by using lower doses of each component.

The detailed results looked at four groups: NIS acetaminophen-opioid toxicity, NIS acetaminophen-alone toxicity, ALFSG acetaminophen-opioid toxicity and ALFSG acetaminophen-alone toxicity. Three different time frame analyses were done for each group: 1) before and after the FDA announcement date in 2011, 2) before and after the FDA implementation date in 2014, and 3) a washout comparison of cases before the 2011 announcement date and after the 2013 implementation date.

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