FDA may move toward updating COVID-19 vaccines for fall booster shots

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FDA may move toward updating COVID-19 vaccines for fall booster shots
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A panel of independent experts advising the Food and Drug Administration is set to recommend Tuesday whether to update existing COVID-19 vaccines to target a newer version of the coronavirus in a booster shot that Americans could get in the fall.

WASHINGTON —

At a meeting Tuesday, the FDA will ask the advisory panel whether a retooled vaccine should aim at a version of the virus in the omicron family. That would leave it to federal regulators to decide exactly which formulation to use in the fall. But a bivalent that targets those subvariants would also be problematic. Neither Pfizer nor Moderna has concentrated on developing one, and no one knows for sure how well it would work. At this late point in the year, using human trials to test such a vaccine, followed by the two months that would be required to manufacture doses, could push the release of any new vaccine well into the next wave of the virus.

But Dr. Paul Burton, Moderna’s medical director, said last week that it’s unlikely that the company could deliver doses until very late this year, or even early next year. The Centers for Disease Control and Prevention has estimated that as of February, 60% of Americans had already been infected with the virus, providing them with at least some temporary immunity. While breakthrough infections among vaccinated individuals are now common, many of the cases are mild.

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