An analysis of the STARRT-AKI trial published in Crit_Care finds that accelerated renal replacement therapy initiation in critically ill patients with acute kidney injury confers a modest reduction of cumulative fluid balance.
]. STARRT-AKI was registered at ClinicalTrials.gov . Ethics approval was granted by research ethics boards at all participating sites, and consent to participate was provided by patients or substitute decision makers; deferred or waived consent was permitted in certain jurisdictions as per local policy.
This planned secondary analysis aimed to evaluate the effect of an accelerated strategy of RRT initiation on fluid accumulation. First, among the 2927 patients who were eligible for the modified intention to treat analysis, we evaluated the difference in cumulative fluid balance, by randomized group, from the day of randomization through their entire ICU stay or up to day 14.
We evaluated effect estimates for each of the outcomes of interest within each quartile: risk ratios for categorical outcomes were estimated using binomial general linear models with log-links, andvalue for trends was estimated as the interaction between quartile and outcome in the models. Mean differences for continuous outcomes were evaluated with
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