From molecular to whole-brain scale in a simple animal, study reveals serotonin's effects MIT CellCellPress
that C. elegans uses serotonin to slow down when it reaches a patch of food and traced its source to a neuron called NSM. In the new study, the team used their many new capabilities developed since then at MIT to examine serotonin's effects comprehensively.
Analysis of all the resulting data revealed at least two key findings: One was that three receptors primarily drove the slowing behavior. The second was that the other three receptors interacted with the receptors that drive slowing and modulated how they function. Thesebetween serotonin receptors in the control of behavior is likely to be directly relevant to psychiatric drugs that target these receptors, Flavell said.
A wiring diagram of the C. elegans worm shows neurons and muscle cells that express receptors for serotonin. Each color denotes a specific receptor. Some neurons express more than one. The diagram appears as a figure in the research paper. Credit: Di Kang/MIT Picower InstituteHaving teased out the roles of the serotonin receptors in the control of C. elegans behavior, the research team then used their imaging technologies to see how serotonin's effects worked at a circuit level.
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