Frontiers | Understanding feeling “high” and its role in medical cannabis patient outcomes

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Frontiers | Understanding feeling “high” and its role in medical cannabis patient outcomes
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Medical cannabis patients who feel 'high' report greater symptomrelief but increased negativesideeffects unm frontiersin

plant, to alter the individual’s visceral sensations, perceptions, and attention would seem to be integral to the treatment’s ability to improve these types of health conditions. This thesis is supported by findings showing that THC potency levels are stronger predictors of patient symptom relief than are CBD levels .

The current study seeks to measure the associations among experiences of feeling high, patient symptom relief, and side effect outcomes during real-time cannabis administration sessions, accounting for plant phenotype, product potency, consumption mode, and dose and testing for differences across health conditions, sex, and age subgroups. We focus on flower products as the most widely used and homogenous product category with comparable percentage-based potency information across products .

To use the Releaf App, patients voluntarily download the free app, available for both Android and iOS devices. Before starting a cannabis session, patients are instructed to record the product characteristics, including product type , and combustion method for “flower” and “concentrate” .

The original sample consisted of 232,256 symptom-specific treatment events during 10,6801 sessions recorded by 13,539 app users between 6/5/2016 and 3/11/2021. Restricting the sample to those treatment events with positive starting symptom intensity levels, i.e., involving a health condition in need of treatment, reduced to sample to 228,835 treatment events, 103,825 sessions, and 12,910 app users.

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