Findings from the biggest genetic study of Alzheimer’s to date may help predict individuals’ risk of the disease and tailor prevention and treatment strategies.
, immune cells in the brain, can play in the disease, says Sims. “Years ago, we were only looking at neurons and how they might be involved in Alzheimer’s, but now we know that these cells are really important too.”
“A lot of drugs may be more useful in certain people than others depending on what type of pathways are involved,” says Sims. “Potentially, the drugs will have a bigger effect if we target the right pathways.” Sims says it is unclear to what extent the findings will be applicable to people of colour. “We need this research funded for other populations.”at the Jackson Laboratory in Bar Harbor, Maine. The finding that genetic risk scores for Alzheimer’s can be made more accurate by including these new genetic variations is particularly significant, she says.
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