A report from large cohorts of adult survivors of childhood cancer demonstrates that polygenic scores improve the risk prediction of developing severe obesity, providing opportunities for surveillance and mitigation interventions YadavSapkota8 StJude
Adult survivors of childhood cancer have high rates of obesity, which, in combination with the cardiotoxic effects of specific cancer therapies, places them at high risk for cardiovascular morbidity. Here we show the contribution of genetic risk scores to increase prediction of those survivors of childhood cancer who are at risk for severe obesity as an adult. Among 2,548 individuals of European ancestry from the St.
Jude Lifetime Cohort Study who were 5-year survivors of childhood cancer, the GRS was found to be associated with 53-fold-higher odds of severe obesity. Addition of GRSs to risk prediction models based on cancer treatment exposures and lifestyle factors significantly improved model prediction , which was independently validated in 6,064 individuals from the Childhood Cancer Survivor Study.
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