Molecular changes in the brain in aftermath of traumatic event may help explain long-term susceptibility or resilience MCG_AUG MolPsychiatry
and decreased neuronal excitability in the dorsal but not ventral CA1 neurons. We further found that corticosterone pretreatment increasedas well as TRIP8b and HCN1 protein expression in the perisomatic CA1 region/neurons of the dorsal hippocampus. Corticosterone-induced functionalwas mediated by the GR, HCN channels, and the PKA but not the CaMKII pathway.
The male CD-1 mice with the attack latency <60 s for at least two sessions on the last day were selected for aggressors in social defeat experiments. For the chronic social defeat procedure, male C57BL/6 J experimental mice were individually introduced into the large home cage of an aggressor CD-1 mouse for 5 to 15 min during which time the experimental mouse was physically and emotionally defeated.