Gout flare-ups could raise heartdisease risk for weeks after JAMA_current
Among patients with gout, is there a transient increase in the risk of cardiovascular events after gout flares?In this case-control study that included 62 574 patients with gout, those who experienced a cardiovascular event, compared with those who did not experience such an event, had significantly greater odds of a recent gout flare in the prior 0 to 60 and 61 to 120 days .These findings suggest gout flares are associated with a transient increase in cardiovascular events following the flare.
Association with recent prior gout flares was measured using adjusted odds ratios with 95% CIs in a nested case-control study and adjusted incidence rate ratios with 95% CIs in a self-controlled case series.Among patients with a new diagnosis of gout , 10 475 patients with subsequent cardiovascular events were matched with 52 099 patients without cardiovascular events.
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