Growing older might not be a one-way street - new insights into the ageing process reveals how it might be possible to turn back time
Rather than the result of the accumulation of wear and tear as time ticks by, ageing could be driven by the forces that build our bodies in the uterus and maintain them after we are born. In youth, they help us, but a failure to switch them off brings the deterioration of old age. This new view offers a deeper understanding of what ageing actually is and the possibility of slowing or even partly reversing it.
While the processes that drive ageing are a matter of debate, biogerontologists do agree on one thing – what it looks like: the progressive decline in physical function that most creatures experience with the passage of time. They have catalogued the cellular changes accompanying this decline, which include crumbling chromosome ends, damaged and unstable genomes and changes in the way that cells sense nutrients.
For many years, biologists have favoured the idea that these hallmarks were the result of damage such as that wrought by reactive molecules called
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