Helicobacter pylori infection found to lower cognition among adults in the UK

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Helicobacter pylori infection found to lower cognition among adults in the UK
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Helicobacter pylori infection found to lower cognition among adults in the UK PLOSONE BYU Hpylori helicobacterpylori cognition infection

By Pooja Toshniwal PahariaJun 9 2023Reviewed by Lily Ramsey, LLM In a recent study published in PLOS ONE, researchers evaluated the association between Helicobacter pylori infection and cognition among adult United Kingdom residents.

The association between infection with H. pylori and cognitive impairments could raise health concerns at the personal and population levels, warranting further research. Individuals were considered H. pylori-seropositive if they were positive for two of the six antibodies against vacuolating cytotoxin A , cytotoxin-associated antigen-A , chaperonin , outer membrane proteins , UreA, and catalase antigens, determined using median fluorescence intensity .

Helicobacter pylori seropositivity and serointensity in the adjusted models were related to worsened reasoning and numeric memory with increased errors in pair matching but improved tower rearrangement performance. lnCagA was related to worsened logic and numeric memory, whereas InVacA, lnCatalase, and InUreA were associated with worsened reasoning.

H. pylori infections could also reduce vitamin B12 levels and absorption of folate, which have been related to elevated homocysteine concentrations, which, in turn, are related to cognitive alterations and dementia.

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