High efficacy of SARS-CoV-2 vaccines in preventing COVID-19 deaths in children and adolescents msalnacion bmj_latest SARSCoV2 COVID19 Death Mortality Adolescent Children Vaccine Vaccination HighEfficacy
By Tarun Sai LomteDec 23 2022Reviewed by Aimee Molineux A recent study published in the BMJ evaluated the effectiveness of coronavirus disease 2019 vaccines in Argentinian children when severe acute respiratory syndrome coronavirus 2 Delta and Omicron variants were predominant.
About the study In the present study, researchers assessed the effectiveness of BNT162b2, mRNA-1273, and BBIBP-CorV vaccines against SARS-CoV-2 infection and associated mortality in children and adolescents in Argentina during Delta and Omicron waves. All individuals tested for SARS-CoV-2 between September 12, 2021, and April 23, 2022, without a previous positive result were included.
The primary and secondary outcomes were SARS-CoV-2 infection, confirmed by reverse-transcription polymerase chain reaction or antigen testing, and COVID-19-associated death. Cases and controls were exact-matched on age, sex, week/type of testing, residential province, and comorbidities. Conditional logistic regression was applied to compare the odds of SARS-CoV-2 infection. Vaccine effectiveness and the corresponding 95% confidence intervals were computed.
However, mRNA vaccines were slightly more effective during the Omicron period than the BBIBP-CorV vaccine . Effectiveness declined with time since vaccination during the Delta wave from 68.4% within 30 days to 65.2% for >61 days in children and from 74.8% to 56.3% in adolescents.
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