High-protein diet counters adaptive thermogenesis in prediabetic individuals HighProteinDiet AdaptiveThermogenesis WeightMaintenance Prediabetes HealthyEating HealthyLiving NutritionResearch WeightLoss DietaryHabits HealthyHabits jnutritionorg
By Dr. Priyom Bose, Ph.D.Apr 24 2023Reviewed by Danielle Ellis, B.Sc. The high rate of obesity has become a growing problem in the modern world. Obesity is associated with the incidence of several comorbidities, such as cardiovascular diseases and type 2 diabetes. Despite weight loss being considered the most important remedy for obesity, long-term weight maintenance is also important.
Energy expenditure adaptations have been found to last multiple years after a weight loss period. Therefore, after weight loss, a reduction in AT is extremely important for long-term weight loss maintenance. Some factors have been identified to reduce AT, such as physical activity, cold-induced brown adipose tissue activation, tea catechins, and capsaicinoids. Furthermore, high protein intake was also linked with AT reduction after weight loss.
The PREVIEW study is associated with three years of weight loss and weight maintenance intervention in four intervention groups. These groups differ in the dietary component, i.e., HP and moderate-protein diet , and physical activity. This study aimed to understand the manifestation of type 2 diabetes after three years of interventions. In addition, the changes in body weight, insulin resistance, and body composition were analyzed.
Study Findings The varied levels of macronutrient composition in the HP and MP diets resulted in the varied protein and carbohydrate balance between the two groups. In the HP group, protein intake and oxidation were higher, which caused a more positive protein balance compared to the MP group. However, compared to the MP group, the carbohydrate balance was less positive in the HP group due to lower carbohydrate intake and oxidation.
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