Move over, mice: Caterpillars could replace some mammals in the study of human disease sloan_kettering NatureComms
The detailed experimental procedure is shown in Fig.. Only animals of the same developmental stage were included in this study. We selected this developmental stage because the animals are very similar in size but also large enough for CT, MR, and PET . Abnormal animals or animals with morphological or behavioral signs of late L5 development were excluded.Bar charts represent mean and SD. Every data point represents a single animal. Source data are provided as a Source Data file.
Unlike vertebrate research animals, working with insects does not require any approval in Europe or the United States.The Bt-infected larvae were imaged at 12, 36, and 42 h post-feeding, while all other treatments were imaged 12 h post-feeding . For immobilization, larvae were cooled for 30 min on ice and then injected into the dorsal vessel with 0.1 ml 0.2 M Gd-BOPTA in 0.9% NaCl or fed with Gd-BOPTA for 12 h.
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