High TNF receptors levels could predict COVID-19 mortality and disease severity Mortality Coronavirus Disease COVID PLOSONE juntendo1838
By Dr. Liji Thomas, MDOct 16 2022Reviewed by Benedette Cuffari, M.Sc. Infection with the severe acute respiratory syndrome coronavirus 2 , which causes the coronavirus disease 2019 , can cause a wide range of symptoms. While most people remain asymptomatic or are mildly affected, a significant minority develop severe or fatal disease.
Introduction COVID-19 may trigger a hyperinflammatory response, or cytokine storm, in some patients. This leads to systemic injury, mediated by damage to the vascular endothelium, with thrombosis within multiple organs. The outcomes include lung damage, acute respiratory distress syndrome , and multi-organ breakdown.
The current study examines possible associations between these markers and severe or fatal COVID-19. This retrospective study was conducted between April and September 2021, wherein the researchers compared biomarker levels among COVID-19 patients who required intensive care unit admission to non-severe COVID-19 patients.
Inflammatory markers, including TNFR1 and TNFR2, were markedly higher among ICU patients as compared to all other levels of severity. In contrast, CRP and interleukin-6 levels showed a graduated increase with the severity of the illness. Conclusions Older males, especially those with lower diastolic pressure, reduced lymphocyte counts, and higher WBC, LDH, and D-dimer levels were at a higher risk of mortality due to COVID-19. In addition, increased inflammatory markers were also associated with a higher risk of mortality.
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