“This emphasizes the critical importance of early HIV diagnosis and an awareness of aging-related problems, as well as the value of preventing HIV infection in the first place,” said th…
LOS ANGELES — HIV-infected individuals often suffer from “substantial” premature aging that can cut nearly five years off a patients’ lifespan, according to new UCLA-led research published Thursday.
“This emphasizes the critical importance of early HIV diagnosis and an awareness of aging-related problems, as well as the value of preventing HIV infection in the first place,” she said.Previous research has suggested that HIV, and antiretroviral therapy to keep the infection under control, are associated with earlier onset of age-related conditions such as heart and kidney disease, frailty, and difficulties with cognition.
The researchers examined five epigenetic measures of aging. Four of them are epigenetic “clocks,” each of which uses a slightly different approach to estimate biologic age acceleration in years relative to chronologic age. The fifth estimates the length of telomeres, protective cap-like parts at the ends of chromosomes that become shorter with age as cells divide until they become so short that cell division is no longer possible.
All participants have regular study visits, usually about six months apart, at which testing for HIV infection is performed, and blood and other samples are collected and stored for research use.
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