CAR-T therapy has been successful at treating cancer. Now, it’s driven lupus into remission in a handful of patients.
The new study suggests a possible treatment for lupus patients who don’t benefit from currently available drugs. “This impressive study adds to the growing body of evidence that CAR-T therapy may be a therapeutic option for diseases beyond cancer, including autoimmune disorders such as lupus,” Jonathan Epstein, executive vice dean and chief scientific officer of the University of Pennsylvania’s Perelman School of Medicine, wrote to WIRED via email.
, but relapse remains common and occurs in 40 to 50 percent of patients. Cancer patients treated with CAR-T therapy can also have a severe inflammatory reaction called cytokine release syndrome. In the lupus study, patients experienced only mild side effects, including fever. “The difference between cancer and autoimmunity is that in cancer, there are usually more cells involved,” says Georg Schett, vice president of research at the University of Erlangen-Nuremberg in Germany, who was part of the study team. When engineered T cells go after so many tumor cells at once, it can over-activate the immune system and release a potentially life-threatening cytokine storm.
Schett’s team is planning a larger study called a basket trial, in which patients with different types of autoimmune conditions, such as rheumatoid arthritis and scleroderma, will be treated with CAR-T therapy. He says longer follow-up in larger clinical trials will be needed to determine whether the therapy is really a cure.for the foreseeable future. Currently, CAR-T therapies for cancer cost around $400,000 for a one-time infusion.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
How Car Commercials Can Be Shot Without the CarThis production company shows how they are able to shoot full commercials for new cars before the first vehicle model ever makes it off the line thanks to high-resolution 360-degree cameras and 3D renders.
Read more »
What Car? is the UK's biggest and best car buyers guide with new and used car reviews, advice, news and videos.
Read more »
Used FORD MUSTANG 1965 for sale1965 Ford Mustang 289 V8 Coupe Beautiful Example, Just 3 owners, Rebuilt Engine, Very Original A stunning, early example of the iconic Ford Mustang. With just 3 owners from new, fully documented history and last enthusiast owner for 32 years! Rebuilt 289 V8, automatic gearbox, original interior and unbelievably solid throughout. A particularly well cared for example which has been featured in multiple books, is well known in the owners club and is ready to be enjoyed. Imported from La Jolla, California in 1990 from the second owner, a lady who had used the car daily for 20 years. A huge file of history accompanies the car, documenting both the mechanical and service work carried out as well as all the events and shows the car has attended since being in the UK. The car starts with ease and drives beautifully with everything working as it should. The V8 is super smooth and pulls very well having been completely rebuilt and the power steering makes the car very usable. A wonderful opportunity to own a real piece of American motoring history, with an unrepeatable history.
Read more »
Joe Biden Mocked for Tweeting About EVs With Pic of Gas CarUS president Joe Biden confused a gas-guzzling Corvette sports car for an electric vehicle in a recent tweet.
Read more »
Car Internet Roasts Biden For Posing Next to Corvette Z06 For EV TweetYeah... that's not an EV, Joe. In fact, the 2023 Corvette Z06 is anything but.
Read more »
Climbing Behind the Wheel of a Hydrogen-Powered Fuel Cell Muscle CarHyundai’s N Vision 74 turns out 690 hp of asphalt-burning rear-drive fun—and makes a great argument for the technology’s place in an electric future.
Read more »