How air pollution affects the central nervous system over time

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How air pollution affects the central nervous system over time
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How air pollution affects the central nervous system over time AirPollution CentralNervousSystem Pollution Neuroinflammation Neurodegeneration Carleton_U Toxics_MDPI

Study: Neuroinflammation and Neurodegeneration of the Central Nervous System from Air Pollutants: A Scoping Review. Image Credit: Hung Chung Chih / Shutterstock

Emission and combustion pollutants create various airborne small particles. Particulate matter emitted by vehicles, industrial plants, power plants, and residential air conditioning systems remains indoors and outdoors and acts as neurotoxicants. Such air pollutants primarily work by inducing inflammatory responses, leading to the generation of free radicals and subsequent tissue damage and neurodegeneration.

Air pollution Air pollution is caused by combinations of solid and liquid particles, including ozone, sulfur dioxide, carbon monoxide, nitrogen oxides, polycyclic aromatic hydrocarbons, and heavy metals. These pollutants are collectively considered PM, which are exponentially increasing in the environment due to urbanization and industrialization.

Air pollutants enter the body through inhalation or ingestion. PM2.5 can easily translocate to the lower respiratory tract and cause respiratory disorders. It can also translocate from the lungs to the blood and, thus, can reach any organs in the body via the circulatory system. Children are more susceptible to pollutant-induced neurotoxicity as they absorb more water and air per unit of body size than adults. Besides neuroinflammation, exposure to air pollutants causes inflammation in the respiratory and gastrointestinal systems. Exposure to PM2.5 has been found to be associated with various diseases, including inflammatory bowel syndrome and cancer.

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