Differences in gutmicrobiome linked to risk of death in COVID-19 patients with respiratory failure NatureComms
Clostridium sporogenes. Our finding that increased concentrations of DAT in fecal samples is associated with recovery from COVID-19 suggests that microbiota-mediated modulation of type I interferon signaling attenuates lung injury in patients with severe SARS-Cov-2 infection.
Our study has several limitations. First, because our study includes patients treated at a single institution, our findings may not readily extend to patients receiving treatment in other medical centers. Second, although we have demonstrated significant associations between the progression of respiratory failure and the paucity of potentially immunomodulatory metabolites, a larger sample size might have identified additional important correlations.
We demonstrate that microbiome composition and a subset of microbiota-derived metabolites are independently associated with survival and the trajectory of respiratory failure among patients admitted to the ICU with COVID-19. Given the malleability of the microbiome’s composition and function, identification and characterization of metabolites associated with improved clinical outcomes may enable therapeutic interventions that include microbiome manipulation and augmentation.
Fecal samples were collected as soon as possible following ICU admission, immediately refrigerated and aliquoted and frozen at −80 C within 24 h. Samples which were collected within the first 72 h of ICU hospitalization at University of Chicago were included in this analysis. This time frame was chosen to focus the study on whether the fecal microbiota in the early course of illness influences clinical trajectories and outcomes.Fecal samples underwent metagenomic shotgun DNA sequencing.
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