Increased paternal age may give rise to disease in the new generation elsevierconnect UniofOxford PaternalAge Disease
By Bhavana KunkalikarNov 8 2022Reviewed by Aimee Molineux In a recent study published in the Fertility and Sterility journal, researchers assessed the effects of paternal age on novel mutations and diseases in the next generation.
Origins of new mutations in humans In the present study, researchers determined how de novo point mutations , a major cause of genetic disease, are affected by paternal age. DNMs and genetic diseases Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year. Download a copy today Data on DNMs from WGS/WES research of large family trios and/or testicular tissues revealed that all humans receive a small but constant amount of novel mutations at each generation. The team also noted a strong paternal bias concerning DNM origin, with most DNMs exhibiting mutational signatures.
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