Severe coronavirus disease 2019 (COVID-19) outcomes in patients with immune-mediated inflammatory diseases (IMIDs).
By Vijay Kumar MalesuMay 3 2024Reviewed by Lily Ramsey, LLM In a recent study published in The Lancet Digital Health, a group of researchers analyzed severe coronavirus disease 2019 outcomes in patients with immune-mediated inflammatory diseases , focusing on the effects of medications, comorbidities, and vaccination status during different pandemic phases.
These conditions are marked by chronic inflammation and immune dysregulation, potentially exacerbating COVID-19 severity. Contributing factors include immune dysfunction, use of immunomodulatory medications , and prevalent comorbidities like heart disease and diabetes. The study was divided into two periods: the pre-omicron phase featuring the wild-type and early variants like alpha and delta, and the omicron-predominant phase .
Statistical analysis utilized machine learning models to parse the data, focusing on patient demographics, vaccination status, active comorbidities, IMID diagnoses, and IMM use. Variables were normalized, and missing data was handled through median imputation. Study results In the large-scale analysis of 2,167,656 patients tested for Severe Acute Respiratory Syndrome Coronavirus 2 , 290,855 were confirmed to have COVID-19, including 15,397 patients with IMIDs and 275,458 without.
In the pre-omicron period, 169,993 of 1,517,295 tested individuals were COVID-19 positive. Among them, 23,330 were hospitalized, 1,072 required mechanical ventilation, and 5,294 died.
Covid-19 Arthritis Asthma Chronic Coronavirus Diabetes Heart Heart Disease Immunomodulatory Inflammation Multiple Sclerosis Omicron Pandemic Research Rheumatoid Arthritis Sclerosis Virus
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