Inhibiting Ovarian Cancer Growth Using Gold Nanoparticles AdvSciNews cancer ovariancancer cancerresearch cancermedicine nanomedicine nanomaterials
By Bhavna KavetiSep 20 2022Reviewed by Susha Cheriyedath, M.Sc. High-grade serous ovarian cancer is among the deadliest human cancers and its prognosis remains extremely poor.
Furthermore, an orthotopic patient-derived xenograft model was used to confirm that the gold nanoparticles inhibited tumor growth in patients with HGSOC. Moreover, to validate the molecular mechanisms underlying the efficacy of gold nanoparticles, a cell line-based human xenograft tumor was treated with gold nanoparticles and PI-103 , individually and as a combination therapy .
Related StoriesMajor efforts in biomedical nanotechnology have focused on drug delivery and biosensor applications. Although the size- and shape-dependent physicochemical and optoelectronic properties of inorganic nanoparticles have been studied in detail, their biological properties remain practically unexplored.
Previously, the self-therapeutic properties of 20-nanometer gold nanoparticles that inhibited tumor growth in two preclinical orthotopic models of ovarian cancer were demonstrated. This took place through through the inhibition of mitogen-activated protein kinase -activation and reversal of epithelial-mesenchymal transition via downregulation of several heparin-binding growth factors.
Exploring the modulation of the protein corona around gold nanoparticles helped identify various new targets, including hepatoma-derived growth factor , survival motor neuron domain containing 1 , inorganic pyrophosphatase , peptidase inhibitor 15 , gasdermin B, and insulin-like growth factors in ovarian cancer.
Conclusion In conclusion, a new regulatory protein, IGFBP2, was identified that facilitated the gold nanoparticles to impair the development and progression of ovarian cancer. Based on the non-toxic dose of gold nanoparticles, the suppression of tumor growth in an orthotopic PDX model mouse was demonstrated.
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