The home side have won 18 games in a row and will retain the title if they avoid defeat - but can Gregor Townsend's men throw a spanner in the works?
Ireland boss Andy Farrell has named an unchanged team from last week's Grand Slam-ending loss to England as they look to wrap up a second successive championship.
The only change for Ireland, who just need a win or a draw to be assured of the title, comes on the bench where Farrell reverts to a 5-3 split between forwards and backs, with fit again centre Garry Ringrose back in the matchday squad. Ireland team: Keenan, Nash, Henshaw, Aki, Lowe, Crowley, Gibson-Park; Porter, Sheehan, Furlong, McCarthy, Beirne, O'Mahony , Van der Flier, Caealan Doris
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