Is it possible for the human brain to be activated by the dying process?

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Is it possible for the human brain to be activated by the dying process?
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Is it possible for the human brain to be activated by the dying process? PNASNews UMichMedSchool brain neuroscience dying human humanbrain activation research

By Pooja Toshniwal PahariaMay 3 2023Reviewed by Lily Ramsey, LLM In a recent study published in PNAS, researchers examined the neuronal activity of the dying human brain before and after the clinical discontinuation of ventilatory aid to investigate whether the dying process may engage the human brain.

Elevation of high-frequency-type oscillations, a possible measure of awareness, has been observed in critically ill individuals. The patients showed no sign of overt consciousness or voluntary behavior on the last day of their lives, as indicated by their Glasgow Coma Scale scores. Results The global hypoxia resulting from withdrawing ventilator support markedly, rapidly, and transiently stimulated γ activities in two patients with a history of seizures, as demonstrated by a rise in absolute electroencephalographic power in the γ frequency bands.

At near death, increases in PAC of γ oscillations, crPAC, and γ synchrony in the posteriorly located hot zones were observed. In addition, long-range γ synchrony between the posterior hot zones and frontal lobes also increased. A decrease in heart rate further enhanced β-γ PAC in the SSCs of the left side, and γ oscillatory movements in those on the right side showed increased inter-regional-type coupling with β oscillations in prefrontal regions.

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