Is there an association between exposure to ultrafine particles during pregnancy and influenza infection severity? BMCMedicine TAMU UF DukeU ultrafine particles pregnancy influenza infection severity womenshealth childrenshealth publichealth
By Bhavana KunkalikarApr 19 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Particle and Fibre Toxicology Journal, researchers explored the impact of exposure to ultrafine particles during pregnancy on the risk of influenza infection.
In the study, pregnant mice were exposed to either UFPs or filtered air equivalent to a 24-hour average of 25 µg/m3 during gestational days 0.5 to 13.5. Results Plug-positive female mice in all exposure cohorts had a pregnancy rate of at least 60%. UFP exposure did not impact pregnancy loss due to comparable pregnancy rates among the groups.
The UFP exposure group showed more PR8 cytopathic effect than the FA exposure group during TCID50 analysis. This was observed through cell lysis, excessive cell rounding, and multifocal cellular destruction.
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