Is there an association between long-term plasma caffeine intake and adiposity, type 2 diabetes, and cardiovascular diseases? bmj_latest UU_University caffeine coffee type2diabetes T2D cardiovasculardisease CVD adiposity
By Neha MathurMay 18 2023Reviewed by Lily Ramsey, LLM In a recent study published in the BMJ Medicine, researchers performed two sample-mendelian randomizations studies to investigate the effects of long-term exposure to higher plasma caffeine concentrations on type 2 diabetes , adiposity, and cardiovascular diseases, such as ischaemic heart disease, stroke, atrial fibrillation, to name a few.
Thus, these studies did not reliably infer causality, potentially resulting in confounded associations. Related StoriesThe researchers assumed that genetic variants used as instrumental variables in MR analysis fulfill three assumptions, relevance assumption, independence assumption, and exclusion restriction assumption.
It helped them investigate the potential causal effects of long-term exposure to higher plasma caffeine concentrations on adiposity, T2D, and major cardiovascular diseases. Per study estimates, BMI reduction mediated 43% of the effect of caffeine on T2D liability. However, for every SD increase in plasma caffeine, genetically predicted higher plasma caffeine concentrations were not associated with fat-free body mass , where one SD was equal to ~11.5 kg.
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