Health charities will provide help and testing support at the event.
Leeds Pride returns for the first full in-person event since the pandemic on Sunday 7 August
Forty-nine cases have been recorded in the Yorkshire and Humber region, out of more than 2,700 cases UK-wide. Chief executive Tom Doyle said: "Anyone with monkeypox can pass it on through close contact, regardless of sexual orientation, but currently gay and bi men are disproportionately affected. Once the fever breaks a rash can develop, often beginning on the face, then spreading to other parts of the body, most commonly the palms of the hands and soles of the feet.
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