In a phase 2a clinical trial in patients with non-alcoholic steatohepatitis, dual inhibition of sodium-glucose cotransporters 1 and 2 with 150mg of licogliflozin led to reductions in serum alanine aminotranferase levels. Pinnacle_TX
< 0.001. Dotted gray line represents end of treatment time point. Data in subfigure a presented as mean % change from baseline, b, as geometric mean ratio to baseline, and c, as mean reduction. Error bars represent s.e.
for placebo, licogliflozin 30 mg, and licogliflozin 150 mg for bodyweight in subgroup with diarrhea: 12, 21, 8 ; 12, 22, 8 ; 11, 21, 5 ; 11, 21, 7 ; 11, 21, 7 ; 10, 19, 7 ; 10, 19, 7 ; bodyweight in subgroup without diarrhea: 9, 21, 30 ; 9, 21, 28 ; 9, 21, 25 ; 9, 21, 27 ; 9, 21, 26 ; 9, 21, 27 ; 9, 21, 27 .
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