Manipulating mitochondrial shape may limit metastaticcancer, study finds naturecancer
This work was supported by grants from CPRIT training grant to P.K.P., NSF grant to M.M.P., NCI grant to R.J.D., Cancer Center Support Grant and CPRIT , ACS , METAvivor , Susan G. Komen Career Catalyst Grant , SCCC Cancer & Obesity Translational Pilot Program Grant, and Breast Cancer–Bone initiative from Charles Y.C. Pak Foundation grants to S.M. We acknowledge Y. Wang for the initial help with astrocytes isolation. We thank K. Luby-Phelps, R. Jackson, P. Doss and A.
Pravat Kumar Parida, Mauricio Marquez-Palencia, Suvranil Ghosh, Kangsan Kim, Vidhya Nair, Yan Peng, Cheryl Lewis & Srinivas Malladi Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA Pravat Kumar Parida, Mauricio Marquez-Palencia, Suvranil Ghosh, Kangsan Kim, Vidhya Nair, Yan Peng, Cheryl Lewis, Carlos L. Arteaga, Ariella B. Hanker, Ralph J.
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Breast cancer mortality in 500 000 women with early invasive breast cancer in England, 1993-2015: population based observational cohort studyObjectives To describe long term breast cancer mortality among women with a diagnosis of breast cancer in the past and estimate absolute breast cancer mortality risks for groups of patients with a recent diagnosis. Design Population based observational cohort study. Setting Routinely collected data from the National Cancer Registration and Analysis Service. Participants All 512 447 women registered with early invasive breast cancer (involving only breast and possibly axillary nodes) in England during January 1993 to December 2015, with follow-up to December 2020. Main outcome measures Annual breast cancer mortality rates and cumulative risks by time since diagnosis, calendar period of diagnosis, and nine characteristics of patients and tumours. Results For women with a diagnosis made within each of the calendar periods 1993-99, 2000-04, 2005-09, and 2010-15, the crude annual breast cancer mortality rate was highest during the five years after diagnosis and then declined. For any given time since diagnosis, crude annual breast cancer mortality rates and risks decreased with increasing calendar period. Crude five year breast cancer mortality risk was 14.4% (95% confidence interval 14.2% to 14.6%) for women with a diagnosis made during 1993-99 and 4.9% (4.8% to 5.0%) for women with a diagnosis made during 2010-15. Adjusted annual breast cancer mortality rates also decreased with increasing calendar period in nearly every patient group, by a factor of about three in oestrogen receptor positive disease and about two in oestrogen receptor negative disease. Considering just the women with a diagnosis made during 2010-15, cumulative five year breast cancer mortality risk varied substantially between women with different characteristics: it was |3% for 62.8% (96 085/153 006) of women but ≥20% for 4.6% (6962/153 006) of women. Conclusions These five year breast cancer mortality risks for patients with a recent diagnosis may be used to estimate breast cancer mortality risks fo
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Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes - Nature CommunicationsEnvironmental conditions during pregnancy contribute to offspring metabolic disease. Here, the authors show that immune cells reprogrammed in utero by maternal vitamin D deficiency increase lifetime diabetes risk in the offspring and are sufficient to transplant diabetes.
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Estimating the impact of COVID-19 vaccine inequities: a modeling study - Nature CommunicationsGlobal COVID-19 vaccine distribution has been inequitable. In this mathematical modelling study, the authors estimate the proportion of deaths that could have been averted in twenty low- and lower-middle-income countries if vaccines had been more widely available early in the pandemic.
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Bristol Festival of Nature celebrates 20th anniversaryThe Natural History Consortium will offer wildlife workshops and events from 9 to 18 June.
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