A male birth control pill has shown promise in mice, but many previous attempts at making an effective and safe contraceptive for men have failed in human clinical trials.
“Safety is very important for birth control pills because people are not taking it for a disease, so they are less tolerant of side effects,” says Noman.He and his colleagues gave male mice a daily dose of a molecule called YCT529 over a four-week period, and found that their sperm count plummeted. Between four and six weeks after the mice stopped receiving the treatment, they could reproduce normally again with no observable side effects.
“When we went to even 100 times higher dose than the effective dose, the compound didn’t show any toxicity,” says Noman, who presented the results today at the American Chemical Society Spring 2022 conference in San Diego, California. The team tested more than 100 molecules to identify a drug candidate that targets a protein called retinoic acid receptor alpha . Inhibiting this protein blocks the effects of retinoic acid, a derivative of vitamin A that plays an important role in cell development and sperm formation.
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