Scientists at the Victor Chang Cardiac Research Institute in Australia have produced a first of its kind integrated map of heart cells which unlocks the process of cardiac fibrosis – a major cause of heart failure.
Victor Chang Cardiac Research InstituteJun 21 2024 Scientists at the Victor Chang Cardiac Research Institute in Australia have produced a first of its kind integrated map of heart cells which unlocks the process of cardiac fibrosis – a major cause of heart failure .
Professor Richard Harvey, who led the study alongside the Institute's Dr Ralph Patrick and Dr Vaibhao Janbandhu, says the discovery is a major step forward in understanding cardiac fibrosis – which accompanies virtually all forms of heart disease including the overloading of the heart due to high blood pressure.
"For the first time, using revolutionary technology that enables us to analyse gene expression in single cells, we have been able to map out the progressive cell states involved in cardiac fibrosis and how these cells evolve day by day." The study identified resting cells, activated cells, an inflammatory population, a progenitor pool, dividing cells, and specialised cells called myofibroblasts and matrifibrocytes.
Dr Vaibhao Janbandhu says: "We found a surprising similarity in fibrosis progression in very different types of heart diseases. Myofibroblasts were abundant early on during hypertension and then resolved into matrifibrocytes, just as they are after a heart attack.
Heart Attack Blood Blood Pressure Cell Drugs Fibrosis Heart Disease Heart Failure High Blood Pressure Mouse Model Muscle Research Scar
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