Maritalstatus likely key factor in predicting early stage gastriccancer survival JIM_AFMR
The aim was to understand which factors reliably predict time from diagnosis until death from any cause.
Based on these data, the researchers built a nomogram to predict 3 and 5-year survivals, in which each variable was scored from 0–100 according to its contribution to survival, and assigned people a high or low risk of recurrence or death. Marital status also showed moderate influence on survival. Married people had the best prognosis, followed by single people, while the prognosis of separated patients was the worst.
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Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma - Infectious Agents and CancerBackground The prognostic value of serum albumin in acquired immunodeficiency syndrome (AIDS)-related lymphoma (ARL) remains covered. Methods We retrospectively analyzed de novo ARL patients from 2013 to 2019 across three centers. Factors correlated with progression-free survival (PFS) and overall survival (OS) were evaluated in Kaplan–Meier, univariate and multivariate Cox proportional hazard models. Results A total of 86 ARL patients were enrolled with a median follow-up of 34 months. In the cohort, the OS and 2-year PFS rates were 37.5% and 35.4%, respectively. In multivariate models, older age (PFS, hazard ratios [HR] = 1.035, p = 0.037; OS, HR = 1.034, p = 0.041) and hypoalbuminemia (OS, HR = 0.910, p = 0.038) predicted inferior survival. ARL patients with hypoalbuminemia showed worse OS and 2-year PFS (p = 0.028 and p = 0.01, respectively), which was associated with poor Eastern Cooperative Oncology Group performance status (ECOG PS) and higher International Prognosis Index (IPI) score. Conclusion In conclusion, serum albumin at diagnosis is an independent prognostic factor for overall survival in AIDS-related lymphoma.
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The impact of rare germline variants on human somatic mutation processes - Nature CommunicationsThe impact of germline variants on somatic alterations in cancer remains to be explored in large-scale datasets. Here, the authors study the association of rare germline variants with somatic mutational processes in more than 15,000 tumors, and reveal that damaging variants in newly-identifed genes are prevalent in the population.
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Ukraine news live: Ukrainian troops plan counter offensive in south of country; Zelenskyy says his forces will 'break' Moscow's willBREAKING: NATO Secretary General Jens Stoltenberg says Finland and Sweden will make the alliance 'stronger' after 30 allies signed an accession protocol to allow the countries to join. Ratification of the bids could take up to a year.
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Insight into Cancer VaccinesCancer vaccines are a relatively new technology in the field of oncology. Read more here.
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Wireless Festival experience 'upsetting' for disabled fansWheelchair users were faced with steep hills, rough gravel and obscured views of the stage.
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