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Dutch study shows the effectiveness of COVID vaccination in reducing hospitalizationsThe study, which is currently available in the medRxiv* preprint server, reveals that the COVID-19 vaccination has prevented a large number of hospitalizations during the pandemic.
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China’s U-Turn on Zero-COVID Shows Xi's Deep ParanoiaChina's reversal on Zero-COVID underscores the fickleness of strongman rule—from suffocating control to callous inaction
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Loss of Y in leukocytes as a risk factor for critical COVID-19 in men - Genome MedicineBackground The COVID-19 pandemic, which has a prominent social and economic impact worldwide, shows a largely unexplained male bias for the severity and mortality of the disease. Loss of chromosome Y (LOY) is a risk factor candidate in COVID-19 due to its prior association with many chronic age-related diseases, and its impact on immune gene transcription. Methods Publicly available scRNA-seq data of PBMC samples derived from male patients critically ill with COVID-19 were reanalyzed, and LOY status was added to the annotated cells. We further studied LOY in whole blood for 211 COVID-19 patients treated at intensive care units (ICU) from the first and second waves of the pandemic. Of these, 139 patients were subject to cell sorting for LOY analysis in granulocytes, low-density neutrophils (LDNs), monocytes, and PBMCs. Results Reanalysis of available scRNA-seq data revealed LDNs and monocytes as the cell types most affected by LOY. Subsequently, DNA analysis indicated that 46%, 32%, and 29% of critically ill patients showed LOY above 5% cut-off in LDNs, granulocytes, and monocytes, respectively. Hence, the myeloid lineage that is crucial for the development of severe COVID-19 phenotype is affected by LOY. Moreover, LOY correlated with increasing WHO score (median difference 1.59%, 95% HDI 0.46% to 2.71%, p=0.025), death during ICU treatment (median difference 1.46%, 95% HDI 0.47% to 2.43%, p=0.0036), and history of vessel disease (median difference 2.16%, 95% HDI 0.74% to 3.7%, p=0.004), among other variables. In 16 recovered patients, sampled during ICU stay and 93–143 days later, LOY decreased significantly in whole blood and PBMCs. Furthermore, the number of LDNs at the recovery stage decreased dramatically (median difference 76.4 per 10,000 cell sorting events, 95% HDI 55.5 to 104, p=6e−11). Conclusions We present a link between LOY and an acute, life-threatening infectious disease. Furthermore, this study highlights LOY as the most prominent clonal mutation affe
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Sheffield steel Covid memorial sculpture design revealedThe steel willow tree will be a tribute to those who died and to key workers, the council says.
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Differences between Covid, Strep A, flu, and common cold including symptomsEvery year during the festive period millions of people fall ill, and while most may just have a common cold, others could be struck down with something more sinister
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