Microbial polyphenols in Mediterranean diet improve cardiovascular health Cardiovascular Disease Diet Mediterraneandiet gut microbiota polyphenols antioxidants UniBarcelona SaludISCIII unav IMIM_research
By Dr. Priyom Bose, Ph.D.Jan 29 2023Reviewed by Benedette Cuffari, M.Sc. In Europe, cardiovascular diseases are one of the leading causes of premature deaths. CVDs are associated with an individual's existing health conditions and habits, such as smoking, hypercholesterolemia, obesity, hypertension, unhealthy food habits, and diabetes mellitus.
Cardiovascular health and diet are closely connected. Nutrients and phytochemicals obtained from diet play a significant role in preventing or incidence of CVDs. Post absorption, microbial phenolic metabolites could be associated with various biological functions. However, limited studies have evaluated the benefits of MPM on cardiovascular health.
The current study applied a linear ion trap quadrupole-Orbitrap-mass spectrometer for the analysis. This technique provided accurate structural information, which helped detect and quantify novel metabolic compounds. None of the study participants achieved the highest recorded ICVH score, which implies that the entire cohort did not meet all seven-health metrics. This observation is consistent with a previous study within the PREDIMED trial, which reported only 0.3% of the cohort achieved scores of six and seven. This finding is not unnatural, as the PREDIMED trial includes the elderly Mediterranean population, which is usually at a higher risk of CVDs.
Strengths and limitations A vital strength of the current study is that it includes the analysis of biological samples, which offers reliable data on an individual's metabolism. Furthermore, LTQ-Orbitrap enabled accurate elucidation and quantification of metabolites.
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