PET imaging shows greater lung inflammation in e-cigarette users than cigarettesmokers
F-NOS non-displaceable binding potential than cigarette smokers and never smoke/vape controls ; whereas BPND in cigarette smokers did not differ from controls .F-NOS lung tissue delivery and iNOS distribution volume did not significantly differ between groups. Although there were no group differences in peripheral inflammatory biomarker concentrations,F-NOS BPND correlated with the pro-inflammatory cytokine tumor necrosis factor-α concentrations in EC users.
Additionally, when EC users and cigarette smokers were pooled together, vaping episodes/cigarettes per day correlated with interleukin-6 levels .This is the first PET imaging study to compare lung inflammation between EC and cigarette users in vivo. We found preliminary evidence EC users had greater pulmonary inflammation than cigarette smokers and never smoke/vape controls, with a positive association between pulmonary and peripheral measures of inflammation.
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