Monkeypox virus infection in an immunocompromised patient TheLancet univmiami infection virus monkeypox HIV AIDS immunocompremised
By Bhavana KunkalikarSep 19 2022Reviewed by Danielle Ellis, B.Sc. In a recent study published in The Lancet, researchers assessed the manifestations of the monkeypox infection in an immunocompromised patient.
Lesions may first appear as macules before developing into papules, pustules, and vesicles before drying up and peeling off. The appearance of skin lesions along with viral prodromal symptoms among immunocompromised patients, in particular, should be evaluated for other diagnoses, such as primary or secondary infection with the varicella zoster virus or other pathogens like Cryptococcus neoformans, Histoplasma capsulatum, or Bartonella henselae.
Related StoriesThe patient denied having recently traveled or come into contact with people or animals with similar rashes or ailments. He stated that he had had all of his childhood vaccines and that he had no prior history of varicella-zoster virus infection. The patient claimed to have had no sexual activity for the preceding six months.
HSV-1, HSV-2, and Treponema pallidum were not detected by immunohistochemical examination of a biopsy sample obtained from one of the truncal papules. Furthermore, spirochetes and fungi were not detected by Warthin-Starry staining or periodic-acid-Schiff staining, respectively. The biopsy sample's histopathological examination revealed focal epidermal necrosis, acute inflammation underneath the superficial dermis, and individually necrotic keratinocytes at the periphery.
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