Nanofiber-Hydrogel Shows Promise For Crohn's Disease Treatment ScienceAdvances JohnsHopkins HopkinsMedicine nanomedicine stemcells stemcell
By Dr. Priyom Bose, Ph.D.Feb 1 2023Reviewed by Megan Craig, M.Sc. Globally, around 6.9 million inflammatory bowel disease cases have been reported and the numbers are continuously increasing. IBD is a multifactorial, complex disease that includes ulcerative colitis and Crohn’s disease . Perianal fistulas are a severe complication of CD, which is resistant to the majority of available treatments.
Prevalence of and Treatment Strategies for Crohn’s disease - Perianal fistulas In the United States, around 780,000 patients suffer from CD, and PAFs occur in around 30% to 40% of these patients. According to a recent estimation, around 15,000 new patients are affected by CD-PAF yearly. Patients with CD-PAF suffer from perianal pain, superimposed infections, frank fecal incontinence, and purulent or feculent drainage. These complications are linked to low quality of life and morbidity.
Related StoriesAnother treatment strategy for PAF in CD is the application of bioprosthetic materials that could serve as fillers for fistula tracts. However, several complications have been associated with this treatment strategy, including surgical site infection and high healing time. Optimization of the composite’s pore size was important because it directly affects the ability of the host’s regenerative cells to migrate into the nanocomposite. To determine optimal material stiffness, mfNHC was subjected to several stiffness levels at HA concentrations of 5, 10, and 15 mg/ml. When the pore size of NHC decreased, the material stiffness increased.
It was hypothesized that ADSCs injected alone would migrate from the injected site, while the mfNHC-ADSC mixture would be retained at the site of infection for a prolonged period. The retention rates of both mfNHC-400 and mfNHC-250 were similar.
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