A Review published in Inflammation and Regeneration finds a correlation between glial phenotypes and the severity of neurodegeneration in Alzheimer's disease. Maintenance of microglial functions may be important in early Alzheimer’s.
Alzheimer’s disease is the most common form of dementia, pathologically characterized by senile plaques and neurofibrillary tangles , resulting in neurodegeneration. Neuroinflammation, defined as the activation of glial cells such as microglia and astrocytes, is observed surrounding senile plaques and affected neurons in AD. Recently conducted genome-wide association studies indicate that a large section of identified AD risk genes are involved in immune responses and are enriched in microglia.
]. AD is pathologically characterized by senile plaques and intracellular neurofibrillary tangles , consisting of
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