A new vaccine against malaria showed promising preliminary results in a large trial in four African countries, but whether the protection has staying power is still not clear.
’s blood-stage surface coupled with a protein from the hepatitis B virus, but the R21 vaccine includes a different immune-boosting agent, known as an adjuvant, from Mosquirix.
Observers had been eagerly awaiting results from the larger trial, which involves 4800 children at five sites in Burkina Faso, Mali, Kenya, and Tanzania with different patterns of malaria exposure. According to the interim data presented yesterday, last year’s results hold up—at least for now.
Faith Osier, a vaccine expert at Imperial College London, notes that some children in the phase 3 trial received their third dose as late as April, and results presented were collected through 1 September. That means “the tail end has only been vaccinated for 6 months,” she says. “It’s very early days in terms of looking at the results.”
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