Scientists have created a new powerful 'masked' cancer drug. Numerous cancer treatments are notoriously harsh on the body; they assault healthy cells simultaneously with tumor cells and result in a wide range of side effects. The Pritzker School of Molecular Engineering (PME) at the University of C
Although interleukin-12 caused adverse side effects, researchers have long hypothesized that it would be a potent cancer treatment. A new form of the molecule has been created by Pritzker Molecular Engineering researchers that does not activate until it enters a tumor, where it kills cancer cells.Numerous cancer treatments are notoriously harsh on the body; they assault healthy cells simultaneously with tumor cells and result in a wide range of side effects.
“The masked IL-12 is largely inactive everywhere in the body except at the site of the tumor, where these proteases can cleave off the mask,” explained Mansurov.The researchers carried out a series of experiments showing that the masked molecule did not cause the inflammation attributed to the unmodified IL-12. In fact, when they tested the effect of the engineered IL-12 in colon cancer, they found that the drug led to the complete elimination of the cancer cells.
“For decades, the field has hoped that IL-12 could someday become a viable therapeutic in the fight against cancer and we’ve now shown that it is possible,” said Mansurov. “We’d like to translate this molecule to the clinic and are now talking to a number of potential partners to make that happen.”
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