A study led by researchers at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine discovered a new relationship between cancer cells and the immune system, and shows how cancer can selfishly hijack a normally helpful immune pathway.
with chromosomal instability and immune cells—and that cooperation is driven by STING."
"But by day five, you have basically no immune response left," Dr. Bakhoum said."The cells became desensitized to this pro-inflammatory pathway very quickly—mirroring the response we saw in the cancer cells. Instead, the cells started to signal stress response pathways that dampened the immune response, thus having the opposite effect."The scientists used a technique called single-cell sequencing to understand all the different cellular players in and around a tumor .
And to understand those impactful interactions between the cancer cells and different immune cells, the researchers developed ContactTracing. By design, the tool exploits the variability of real-world biology without the need for prior knowledge. "When you look at the effects that elicit a response in the cancer microenvironment, all the ligands on those chromosomally unstable cancer cells were associated with a specific cellular stress response—one that happens to involve STING," she said.
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