An article published in the journal Carbohydrate Polymers presented a new methodology to functionalize the chitosan nanocrystals with peptides and amino acids via solid phase peptide synthesis.
By Bhavna KavetiSep 20 2022Reviewed by Susha Cheriyedath, M.Sc. Antimicrobial peptides have a broad spectrum of antimicrobial activity and lyse microbial cells by interaction with biomembranes, offering great potential in designing new therapeutics. The antimicrobial resistance caused due to overuse of antibiotics can be circumvented by using AMPs as alternatives to antibiotics.
The resulting rod-shaped functionalized chitosan nanocrystals were characterized using dynamic light scattering , nuclear magnetic resonance , transmission electron microscopy imaging, and zeta potential measurements. This synthetic strategy can be designed to generate target-specific nanomaterials based on chitosan nanocrystals through the attached peptides on the surface of the nanomaterials.
Related StoriesChitosan nanoparticles combine the natural properties of polymers with tunable sizes and the possibility of surface modification according to requirements. Thus, chitosan nanoparticles are a promising and versatile strategy to overcome most active ingredients' bioavailability and stability issues.
Because of their cationic and nanometre dimensions, several reports have mentioned chitosan nanoparticles in drug delivery systems. The primary amino groups present on the surface of the chitosan nanomaterial facilitated surface functionalization to impart tunable properties to the chitosan derivatives.
Here, solid-phase peptide synthesis involves assembling the peptide chain through a series of coupling and decoupling reactions of amino acids on an insoluble resin, followed by cleavage of the desired peptide chain from the resin. Conclusion Overall, a new methodology was developed to modify the surface of chitosan nanocrystals by utilizing peptides and amino acids of different lengths via solid-phase peptide synthesis. This strategy used the primary amine functional groups present on the surface of chitosan nanocrystals and carboxyl groups of amino acid residues in organic solvents to produce peptide-modified chitosan nanocrystals.
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