Neuroblastomas are tumors of the nervous system. They can form in many places in the body and are the most common cause of cancer-related deaths in young children. A team of researchers at University Medicine Halle has discovered the processes involved in the development of neuroblastomas.
The protein IGF2BP1 is considered the spark that can ignite a whole wildfire of cancer-causing processes. In preclinical trials, the team used a molecule that was able to inhibit IGF2BP1 and extinguish this spark. The results of this new potential therapeutic approach have been published in the journalThe protein IGF2BP1 is present at the beginning of life and ensures that cells grow rapidly during embryonic development. Later on, its presence is linked to various tumors.
The result is an out-of-control conflagration in the cell, which causes neuroblastomas to form, survive, grow and spread. The study has shown for the first time that IGF2BP1 on its own is enough to trigger these tumors; all of the mice in which the protein IGF2BP1 was induced developed a neuroblastoma.More than half of children with high-risk neuroblastomas relapse. Therefore, new therapeutic approaches are urgently needed to more effectively treat this type of childhood cancer.
Professor Hüttelmaier has been studying the protein IGF2BP1 for more than 20 years."We began by studying neurons until we suddenly stumbled upon the fact that this
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