Jane Fonda announces that she has non-hodgkin lymphoma. Here is an updated reference on this condition.
NHLs may result from chromosomal translocations, infections, environmental factors, immunodeficiency states, and chronic inflammation.Chromosomal translocations and molecular rearrangements play an important role in the pathogenesis of many lymphomas and correlate with histology and immunophenotype.
The t translocation occurs between the nucleophosmin gene and the anaplastic lymphoma kinase gene. It results in the expression of an aberrant fusion protein found in a majority of anaplastic large cell lymphomas. Human T-cell leukemia virus type 1 causes a latent infection via reverse transcription in activated T-helper cells. This virus is endemic in certain areas of Japan and the Caribbean islands, and approximately 5% of carriers develop adult T-cell leukemia or lymphoma.
Kaposi sarcoma–associated herpesvirus is associated with body cavity–based lymphomas in patients with HIV infection and in patients with multicentric Castleman disease.infection is associated with the development of primary gastrointestinal lymphomas, particularly gastric mucosa-associated lymphoid tissue lymphomas.Environmental factors linked to the development of NHL include chemicals , chemotherapy, and radiation exposure.
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